Something new is stirring along the coast of Maine, carrying the unmistakable scent of salt water and stubborn charm. Best Medicine is bringing a doctor to a town he never wanted to call home, hauling baggage no medical degree can fix. Around him waits a community full of characters, all open arms and even louder opinions. Every corner of this story is filled with people who feel instantly familiar, yet entirely their own.

While the premise borrows its bones from a beloved British original, the cast breathes brand new life into every frame.

Josh Charles takes on Dr. Martin Best, a Harvard-trained vascular surgeon whose brilliance rarely extends to human warmth. A sudden blood phobia forces him out of his high-pressure Boston career and back to the coastal town where his childhood summers once played out. Charles leans fully into the clipped tone and buried vulnerability that made the original character so magnetic, giving the town a doctor who resists healing even as everyone around him quietly insists on it.

As Martin settles uneasily into small-town rhythms, one woman refuses to let him hide behind his diplomas.

Abigail Spencer plays Louisa Gavin, the sharp schoolteacher who becomes both Martin's biggest challenge and his steadiest anchor. Louisa carries her own tangled history in Port Wenn, including a past engagement that still echoes through local gossip. Spencer brings intelligence and quiet resolve to the role, building a tension with Martin that feels lived-in from the very first scene.

While Louisa keeps Martin honest, the town sheriff has his own complicated ties to her past.

Josh Segarra portrays Sheriff Mark Mylow, a good-hearted lawman better known for warmth than sharp instincts. Mark happens to be Louisa Gavin's former fiancé, a detail that colors nearly every interaction he has with the new doctor. Segarra balances comic timing with real sincerity, turning Mark into someone audiences root for even when his judgment wanders off course.

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As Mark keeps the peace outdoors, someone else is left holding the clinic together indoors.

Cree plays Elaine Denton, Martin's endlessly patient assistant who dreams of internet stardom while managing his overflowing clinic. Elaine is tech-savvy and ambitious, constantly exasperated by her boss, yet her loyalty never wavers no matter how difficult he becomes. Cree gives the character a modern energy that pulls the town firmly into the present, bridging old-world formality with a scroll-happy generation.

While Elaine manages the clinic's chaos, old family history waits just outside its doors.

Annie Potts stars as Aunt Sarah, Martin's blunt aunt and a working lobsterwoman who still heads out on the water daily. Sarah carries old family secrets that slowly surface as her nephew reluctantly resettles into town life. Potts delivers quiet strength and dry affection, making Sarah feel like the emotional backbone of the entire town.

As family ties tighten around Martin, the town's social fabric reveals itself through its restaurant owners.

Stephen Spinella plays Greg Garrison, one half of the couple behind The Salty Breeze, the town's beloved seafood spot. Jason Veasey plays George Brady, Greg's husband and steady co-owner, rounding out a partnership the two proudly call their own dynamic duo. Spinella brings theatrical flair while Veasey grounds the pairing with quiet warmth, together forming one of the town's most settled relationships.

While Greg and George welcome every visitor with open arms, the town's working class adds its own rougher edges.

John DiMaggio plays Bert Large, the local handyman whose blunt personality frequently collides with Martin's medical cases. Carter Shimp plays Al, Bert's son, who keeps stumbling into the same minor crises that fill his father's days. DiMaggio brings gruff comic timing while Shimp adds a restless younger energy, giving the Large family a recurring presence throughout the season.

As the Large family stirs up trouble, two more locals keep the town's opinions firmly in order.

Clea Lewis plays Sally Mylow, the town pharmacist whose practical presence often intersects with clinic business. Didi Conn plays Geneva Potter, a councilwoman with firm opinions on how the town should run its affairs. Lewis brings a crisp, no-nonsense tone while Conn injects comic authority, rounding out a town where everyone seems to have a stake in Martin's every move.

While the town keeps its own order, Martin's past finally arrives in the flesh.

In a fitting full-circle move, original Doc Martin star Martin Clunes appears as Dr. Robert Best, Martin's headstrong gastroenterologist father. Robert's visit forces his son to confront old family history and defenses built over years of avoidance. Clunes plays the role with the same dry intensity that defined the original series, creating a striking mirror to Josh Charles's performance across the season. As comedy series keep piling onto Netflix's ever-growing roster, Best Medicine stands out by folding a medical twist into its small-town charm, giving the show room for genuine heart alongside its laughs.

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What are your thoughts on the full cast lineup for Netflix's Best Medicine? Let us know in the comments.