Variety’s Actors on Actors series is basically the gold standard for celebrity chats—always delivering that deep dive into the acting grind with pairs of stars swapping craft secrets. Since its debut on PBS SoCal in 2014, it has been a can-not-miss show for anyone who loves acting realness. Season 21 crushed it with the most buzz-worthy social rollout ever, and now hype for Season 22 in 2025 is through the roof, with an epic cast ready to light up the screen. 

As excitement skyrockets for Season 22, here is the ultimate ranking of the star-studded cast ready to bring their A-game to Actors on Actors. 

When on-screen sparks ignite off-screen buzz, Keri Russell and Scott Speedman are a prime example. The Felicity co-stars dated in their twenties, stayed close after, and still gush about each other with warmth and humor.

From romantic missteps to lifelong friendship, their bond has stood the test of time. Now, this iconic duo is reuniting to light up Actors on Actors in 2025—nostalgia and chemistry guaranteed.

The next pair of Actors on Actors is Cooper Koch and Sam Nivola, both part of The White Lotus universe. In Season Three, their characters—Lochlan and Saxon Ratliff—sparked outrage and fascination with a shocking twist: a relationship that pushed the boundaries of television storytelling.

Nivola even broke his nondisclosure agreement to warn friends about the jaw-dropping scene. Now, the pair behind the chaos reunites to maybe dive into the craft, the controversy, and everything in between.

Parker Posey and Lisa Kudrow, fresh off their hilariously twisted roles in the horror-comedy The Parenting, are teaming up again for Actors on Actors. Filmed in spooky Massachusetts, the two played snarky pseudo-sisters with nonstop banter and sarcastic sass.

Their dynamic was part sisterly bonding, part savage roast battle. Now, they are ready to bring that same sharp wit and chaotic chemistry to the conversation couch—and honestly, we are here for it.

Javier Bardem and Diego Luna first crossed paths in 2000 in Before Night Falls, with Luna playing Bardem’s character’s childhood buddy. 

Later, they both worked behind the scenes on the now-canceled Amazon miniseries Cortés y Moctezuma, alongside Gael García Bernal. However, the project was cancelled in early 2020. Now, these legends are reuniting once more as guests on Actors on Actors.

Your Top 8 Cult Documentaries on Netflix in 2025 to Binge-Watch Some Darkest Corners of Human Obsession

Joe Locke, breakout star of Heartstopper, and Charlie Cox, best known for playing Daredevil, are teaming up—but not in a superhero flick. The two British talents have been paired for an upcoming episode of Actors on Actors.

The episode has already been filmed and is expected to be released soon, and the pairing has sparked major buzz online.

Amanda Seyfried and Adam Brody, who previously shared the screen in Jennifer’s Body and later portrayed adult film legends in Lovelace, are reuniting in a whole new spotlight.

Brody once credited Seyfried for helping him land the role in Lovelace, and now, the duo is set to spark fresh buzz as they sit down together for an episode of Actors on Actors on June 9th.

Kate Hudson and Kathryn Hahn, a dynamic duo with serious on-screen chemistry, first teamed up in the beloved rom-com How to Lose a Guy in 10 Days and reunited two decades later in Netflix’s Glass Onion: A Knives Out Mystery, playing the stylish Birdie Jay and sharp Claire Debella.

Known for their hilarious banter and genuine friendship, the pair is now set to light up Actors on Actors on June 12th with their signature charm and infectious energy.

Adam Scott and Kristen Bell have crossed paths in The Good Place and Party Down—bringing their unique spark to every project. While they are not Hollywood's go-to duo, their offbeat chemistry and solid friendship have always stood out.

Now, with the two set to appear together on an upcoming episode of Actors on Actors, anticipation is at an all-time high. Expect wit, weirdness, and plenty of charm.

Sterling K. Brown, acclaimed for his powerful performances in This Is Us and The People v. O.J. Simpson, and Natasha Rothwell, the scene-stealing star of Insecure and The White Lotus, are about to bring their brilliance together.

Both celebrated for their range and charisma, the two are set to appear on an upcoming episode, and fans are buzzing with excitement to see what this powerhouse pairing will deliver.

Hanumankind’s Global Reign Hits a New High With Live Netflix Tudum 2025 Performance

Kathy Bates and Billy Bob Thornton, no strangers to sharing the screen, previously teamed up in Primary Colors and brought chaotic family vibes to Bad Santa 2, where Bates hilariously played Thornton’s tough-as-nails mother.

Their dynamic continues to evolve as they reunite in the upcoming Television series Landman. With their sharp performances and unmistakable chemistry, the duo is once again ready to capture audiences—and stir up some serious buzz.

Seth Rogen and Jason Segel first bonded on Freaks and Geeks, where they nearly auditioned for the same role—plus, they once bombed an 8 Mile audition together after bursting into laughter.

Known for their hilarious chemistry in Knocked Up, the duo is teaming up again. Fans are eager to see what fresh comedic magic they will cook up this time around.

Arnold Schwarzenegger, legendary for his iconic roles in The Terminator and his political stint as California’s governor, who has previously shared his root foundation that led to his success, and his son, Patrick Schwarzenegger, rising star of The White Lotus and Gen V, have not shared the screen yet.

However, the father-son duo is set to appear together on Actors on Actors, sending fans into a frenzy. Expect a fascinating mix of Hollywood legacy and fresh talent in one episode.

Dave Chappelle and Mo Amer first teamed up on Narcy’s track 'COMMUNITY'. Since 2015, Amer has toured with Chappelle and made history with his one-hour special Legally Homeless, becoming a trailblazer for Arab-American comedians.

Now, as these two comedy legends prepare to sit down together, fans are eager to see what sharp wit and stories they will bring to the table.

Colin Farrell and Danny DeVito, both unforgettable as Batman’s notorious Penguin, are teaming up for Variety’s Actors on Actors on June 2nd. Farrell brought the character to life in The Batman and The Penguin series, while DeVito’s iconic turn was in Batman Returns.

They also shared the screen in Dumbo. Now, as these two legends sit down together, fan excitement is absolutely off the charts.

After Three Netflix Films, Lindsay Lohan Says, “I can’t do movies like these forever”

What do you think about the pairs? Let us know in the comments below!